VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Pangolin

Scientific Name: Manis javanica

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis

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Hepacivirus C

Family: Flaviviridae

Receptor: LDLR

Receptor LDLR information

Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0035 2021.04 10X Genomics Duodenum Normal 1482 Link
Vthunter_0036 2021.04 10X Genomics Esophagus Normal 24581 Link
Vthunter_0037 2021.04 10X Genomics Heart Normal 12958 Link
Vthunter_0038 2021.04 10X Genomics Kidney Normal 4481 Link
Vthunter_0039 2021.04 10X Genomics LargeIntestine Normal 3328 Link
Vthunter_0040 2021.04 10X Genomics Liver Normal 5694 Link
Vthunter_0041 2021.04 10X Genomics Lung Normal 13720 Link
Vthunter_0042 2021.04 10X Genomics Spleen Normal 3207 Link
Vthunter_0043 2021.04 10X Genomics Stomach Normal 12485 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of LDLR in human tissues   [NCBI]

Expression: Ubiquitous expression in adrenal (RPKM 29.0), lung (RPKM 28.5) and 25 other tissues?

Protein expression of LDLR in human tissues   [Proteinatlas]